Learn more about a topical PDE4 inhibitor for atopic dermatitis from dermatologist Dr. Maxwell B. Sauder
Topical PDE4 (phosphodiesterase 4) inhibitors are steroid-free eczema therapies that have been available in Canada since 2018. Topical PDE4 offer another option to help manage atopic dermatitis. Eczema Society of Canada asked dermatologist Maxwell B. Sauder, MD, FRCPC, FAAD, FCDA, about the topical PDE4 inhibitor Eucrisa™(crisaborole) and how it is used to treat atopic dermatitis (AD), the most common form of eczema.
What are topical PDE4 inhibitors?
Topical PDE4 inhibitors block the enzyme phosphodiesterase 4 (PDE4) from allowing excess inflammation to occur in the skin. Cells in our immune system produce PDE4, which promotes the production of cytokines, proteins that contribute to inflammation. Sometimes, as in the case of AD, cytokines are mistakenly elevated in the body, leading to inflammation that can result in AD flares.
What is Eucrisa™?
Eucrisa™ is a steroid-free topical PDE4 inhibitor used for the treatment of AD in patients 3 months of age and older. Clinical trial data shows a reduction in AD symptoms such as itching, redness, dryness and skin thickening.1
How do I use Eucrisa™?
Eucrisa™ comes in a 2% topical ointment and is applied to the skin twice daily to the affected areas for the management of active disease. It is indicated as safe for use on all skin surfaces; however, it should not be applied directly into the eyes, mouth, or vagina. Speak with your health care professional to learn more about this treatment.
Does Eucrisa™ come in a cream or an ointment?
Eucrisa™ comes in an ointment base (sometimes called a “vehicle”). This base is a specially formulated petrolatum ointment that acts as a moisturizer for the skin and contains the active medicine ingredients.
Do I apply a moisturizer with Eucrisa™?
There is no need to apply a moisturizer under or over Eucrisa™ as the vehicle is hydrating to the skin. Adding a moisturizer could change how the treatment works.
Will this medication sting or burn my skin?
Some users report a temporary feeling of burning or heat when Eucrisa™ is first applied. Speak with your prescribing health care professional about how to use your topical treatments.
Does Eucrisa™ have side effects?
Common side effects are patients experiencing temporary burning, heat or pain upon application of the medication. If you or your child are experiencing this or have any concerns about the treatment, you should consult the prescribing health care professional. All medications have risks and benefits, and the details of the risks and benefits should be reviewed with the prescribing health care professional.
What is maintenance therapy?
AD is a chronic condition, meaning it may clear up for periods of time after treatment, but then it may flare up again. Eucrisa™ is approved for use as maintenance therapy, meaning it is used between flares. Sometimes, health care professionals recommend this treatment method to help prolong the time between flares.
The medication can be applied topically once daily to areas of skin that typically flare. If a health care professional, like a dermatologist, recommends this type of treatment plan, ensure you follow their instructions. If you have any concerns about the treatment, consult your prescribing health care professional or pharmacist.
What if my atopic dermatitis does not get better?
If you find your AD is not responding to treatment, let your health care professional know, as your treatment plan may need to be adjusted. A qualified health care professional, such as a dermatologist, can help reassess your or your child’s condition and can potentially adjust the treatment plan. There is no cure for AD, but there are now many treatments that can help patients.
Eczema Society of Canada thanks Maxwell B. Sauder, MD, FRCPC, FAAD, FCDA, for his volunteer contribution to this educational content.
Reference: 1 Pfizer Canada (August 2023). EucrisaTM (crisaborole) [Product Monograph], Phosphodiesterase-4 (PDE-4) Inhibitor.
Disclaimer: Information provided in this resource does not constitute medical advice and is not intended to be used as a diagnostic tool. The information is up-to-date at time of publication. All medications, interventions, and treatment plans have risks and benefits, and it is important that individuals discuss their or their child’s specific health care needs with a qualified health care professional.
